Latent Space: The AI Engineer Podcast

Latent.Space

Latent Space: The AI Engineer Podcast

Latent.Space

The podcast by and for AI Engineers! In 2025, over 10 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimodality, AI Agents, GPU Infra and more, directly from the founders, builders, and thinkers involved in pushing the cutting edge. Striving to give you both the definitive take on the Current Thing down to the first introduction to the tech you'll be using in the next 3 months! We break news and exclusive interviews from OpenAI, Anthropic, Gemini, Meta (Soumith Chintala), Sierra (Bret Taylor), tiny (George Hotz), Databricks/MosaicML (Jon Frankle), Modular (Chris Lattner), Answer.ai (Jeremy Howard), et al. Full show notes always on https://latent.space www.latent.space [https://www.latent.space?utm_medium=podcast]

1 DAYS AGO

METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity

This is a free preview of a paid episode. To hear more, visit www.latent.space AIE Europe CFP and AIE World’s Fair paper submissions for CAIS peer review are due TODAY - do not delay! Last call ever. We’re excited to welcome METR for their first LS Pod...

2 DAYS AGO

[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka

Swyx joined SAIL! Thank you SAIL Media, Prof. Tom Yeh, 8Lee, Hamid Bagheri, c9n, and many others for tuning into SAIL Live #6 with Nathan Lambert and Sebastian Raschka, PhD. Sharing here for the LS paid subscribers. We covered: This is a public epi...

3 DAYS AGO

🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI

Editor’s note: CuspAI raised a $100m Series A in September and is rumored to have reached a unicorn valuation. They have all-star advisors from Geoff Hinton to Yann Lecun and team of deep domain experts to tackle this next frontier in AI applications. In ...

4 DAYS AGO

Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis

This is a free preview of a paid episode. To hear more, visit www.latent.space First speakers for AIE Europe and AIEi Miami have been announced. If you’re in Asia/Aus, come by Singapore and Melbourne. AI Engineering is going global! One year ago today,...

5 DAYS AGO

⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data

Olivia Watkins (Frontier Evals team) and Mia Glaese (VP of Research at OpenAI, leading the Codex, human data, and alignment teams) discuss a new blog post (https://openai.com/index/why-we-no-longer-evaluate-swe-bench-verified/) arguing that SWE-Bench Verif...

Feb 19

Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z

Tickets for AIEi Miami and AIE Europe are live, with first wave speakers announced! From pioneering software-defined networking to backing many of the most aggressive AI model companies of this cycle, Martin Casado and Sarah Wang sit at the center of the ...

Feb 12

AI Ready

Owning the AI Pareto Frontier — Jeff Dean

From rewriting Google’s search stack in the early 2000s to reviving sparse trillion-parameter models and co-designing TPUs with frontier ML research, Jeff Dean has quietly shaped nearly every layer of the modern AI stack. As Chief AI Scientist at Google an...

Feb 12

🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery

This podcast features Gabriele Corso and Jeremy Wohlwend, co-founders of Boltz and authors of the Boltz Manifesto, discussing the rapid evolution of structural biology models from AlphaFold to their own open-source suite, Boltz-1 and Boltz-2. The central t...

Feb 06

The First Mechanistic Interpretability Frontier Lab — Myra Deng & Mark Bissell of Goodfire AI

From Palantir and Two Sigma to building Goodfire into the poster-child for actionable mechanistic interpretability, Mark Bissell (Member of Technical Staff) and Myra Deng (Head of Product) are trying to turn “peeking inside the model” into a repeatable pro...

Jan 28

🔬 Automating Science: World Models, Scientific Taste, Agent Loops — Andrew White

Editor’s note: Welcome to our new AI for Science pod, with your new hosts RJ and Brandon! See the writeup on Latent.Space for more details on why we’re launching 2 new pods this year. RJ Honicky is a co-founder and CTO at MiraOmics (https://miraomics.bio/)...

Jan 28

🔬 Automating Science: World Models, Scientific Taste, Agent Loops — Andrew White

Editor’s note: Welcome to our new AI for Science pod, with your new hosts RJ and Brandon! See the writeup on Latent.Space (https://Latent.Space) for more details on why we’re launching 2 new pods this year. RJ Honicky is a co-founder and CTO at MiraOmics (...

Jan 27

AI Ready

⚡️ Prism: OpenAI's LaTeX "Cursor for Scientists" — Kevin Weil & Victor Powell, OpenAI for Science

From building Crixet in stealth (so stealthy Kevin had to hunt down Victor on Reddit to explore an acquisition) to launching Prism (https://openai.com/prism/) as OpenAI's free AI-native LaTeX editor, Kevin Weil (VP of OpenAI for Science) and Victor Powell ...

Jan 23

Captaining IMO Gold, Deep Think, On-Policy RL, Feeling the AGI in Singapore — Yi Tay

From shipping Gemini Deep Think and IMO Gold to launching the Reasoning and AGI team in Singapore, Yi Tay has spent the last 18 months living through the full arc of Google DeepMind’s pivot from architecture research to RL-driven reasoning—watching his tea...

Jan 23

Captaining IMO Gold, Deep Think, On-Policy RL, Feeling the AGI in Singapore — Yi Tay

From shipping Gemini Deep Think and IMO Gold to launching the Reasoning and AGI team in Singapore, Yi Tay has spent the last 18 months living through the full arc of Google DeepMind's pivot from architecture research to RL-driven reasoning—watching his tea...

Jan 17

Brex’s AI Hail Mary — With CTO James Reggio

From building internal AI labs to becoming CTO of Brex, James Reggio has helped lead one of the most disciplined AI transformations inside a real financial institution where compliance, auditability, and customer trust actually matter. We sat down with Re...

Jan 17

AI Ready

Brex’s AI Hail Mary — With CTO James Reggio

Jan 09

Artificial Analysis: The Independent LLM Analysis House — with George Cameron and Micah Hill-Smith

don’t miss George’s AIE talk: https://www.youtube.com/watch?v=sRpqPgKeXNk —- From launching a side project in a Sydney basement to becoming the independent gold standard for AI benchmarking—trusted by developers, enterprises, and every major lab to navig...

Jan 08

Artificial Analysis: The Independent LLM Analysis House — with George Cameron and Micah-Hill Smith

Jan 08

Artificial Analysis: The Independent LLM Analysis House — with George Cameron and Micah-Hill Smith

Jan 08

Artificial Analysis: Independent LLM Evals as a Service — with George Cameron and Micah-Hill Smith

Happy New Year! You may have noticed that in 2025 we had moved toward YouTube as our primary podcasting platform. As we’ll explain in the next State of Latent Space post, we’ll be doubling down on Substack again and improving the experience for the over 10...