Essentials: How to Build Endurance
Huberman Lab
2025/04/17
Essentials: How to Build Endurance
Essentials: How to Build Endurance

Huberman Lab
2025/04/17
Shownote
Shownote
In this Huberman Lab Essentials episode, I explain how to build endurance and describe targeted protocols to enhance different types of endurance.
I discuss how endurance—the ability to sustain effort—requires the coordination of physical and mental systems driven by energy availability, brain willpower, and specific training adaptations in the muscles, heart, lungs and neurons. I explain conditioning protocols designed to enhance four types of endurance, from long-duration steady state to muscular endurance and high-intensity intervals, and how each training style triggers unique adaptations in the body and brain, such as improved mitochondrial function and oxygen utilization. Additionally, I highlight the crucial role of hydration and electrolytes, which are essential for neural function and influence the brain’s willpower to sustain effort.
Read the episode show notes at hubermanlab.com.
Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch or listen to the full-length episode at hubermanlab.com.
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Timestamps
00:00:00 Huberman Lab Essentials; Build Endurance
00:00:50 Energy Sources, ATP, Oxygen
00:04:14 Neurons & Willpower, Glucose & Electrolytes
00:09:19 Heart, Lungs; Physiology & Performance Limiting Factors
00:10:35 Sponsor: AG1
00:12:30 Muscular Endurance, Protocol, Concentric Movements, Mitochondria
00:19:10 Sponsors: LMNT & Eight Sleep
00:22:00 Long-Duration Endurance, Efficiency, Mitochondria, Capillaries
00:25:54 High-Intensity Interval Training (HIIT), Anaerobic Endurance, Protocol
00:32:33 High-Intensity Aerobic Endurance, Adaptations
00:35:30 Sponsor: Function
00:37:26 Brain & Body Adaptations, Heart
00:40:40 Hydration, Tool: Galpin Equation
00:42:21 Supplements, Stimulants, Magnesium Malate
00:43:11 Recap & Key Takeaways
Disclaimer & Disclosures
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Highlights
Highlights
This podcast delves into the science of building endurance, focusing on the coordination between physical and mental systems. It explores how energy availability, willpower, and targeted training adaptations contribute to enhancing different types of endurance, from long-duration steady-state activities to high-intensity intervals.
Chapters
Chapters
Huberman Lab Essentials; Build Endurance
00:00Energy Sources, ATP, Oxygen
00:50Neurons & Willpower, Glucose & Electrolytes
04:14Heart, Lungs; Physiology & Performance Limiting Factors
09:19Sponsor: AG1
10:35Muscular Endurance, Protocol, Concentric Movements, Mitochondria
12:30Sponsors: LMNT & Eight Sleep
19:10Long-Duration Endurance, Efficiency, Mitochondria, Capillaries
22:00High-Intensity Interval Training (HIIT), Anaerobic Endurance, Protocol
25:54High-Intensity Aerobic Endurance, Adaptations
32:33Sponsor: Function
35:30Brain & Body Adaptations, Heart
37:26Hydration, Tool: Galpin Equation
40:40Supplements, Stimulants, Magnesium Malate
42:21Recap & Key Takeaways
43:11Transcript
Transcript
Andrew Huberman: Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance. I'm Andrew Huberman, and I'm a professor of neurobiology and oph...