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Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy

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Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy

Huberman Lab

2025/07/21
Huberman Lab

Huberman Lab

2025/07/21
OverviewShownoteHighlightsTranscriptChaptersPins

Shownote

My guest is Dr. Chris McCurdy, PhD, FAAPS, professor of medicinal chemistry at the University of Florida and a world expert on the pharmacology of kratom and other plant-derived medicinal compounds. We discuss kratom’s wide-ranging effects, including its u...

Highlights

In this episode, Dr. Chris McCurdy, a leading expert on kratom and plant-derived medicinal compounds, discusses the complex nature of kratom, its effects on the body, and its potential uses and risks. The conversation delves into the differences between traditional and modern consumption methods, the pharmacological properties of alkaloids, and the broader context of natural medicines in today’s healthcare landscape.
00:00
Kratom's effects on the nervous system and addiction potential discussed
02:51
Kratom is used traditionally for energy, mood, and pain relief, with effects varying by dose.
13:47
The little blue bottle has a dosage similar to traditional exposure.
17:00
Kratom energy shots sold next to regular energy shots pose accidental consumption risks, especially for kids.
26:32
Kratom is often used as an alternative to opioids for pain relief.
32:53
Kratom has three main usage patterns in the US: energy boost, opioid-like effects, and opiate addiction avoidance.
37:03
Alkaloids like kratom can interact with proteins through charged nitrogen
54:14
Nature has solutions for every disease, according to former pharmacist.
1:16:35
Kratom-derived 7-hydroxymitragynine may cause opioid-like respiratory depression in rats

Chapters

Chris McCurdy
00:00
Kratom (Mitragyna speciosa), Origin, Effects, Low vs High Doses
02:51
Sponsors: David Protein & Eight Sleep
07:19
Kratom, Traditional Use vs Commercial Kratom Products, Absorption
10:07
Kratom Products, Serving Size, Kids; Semi-Synthetics; Tool: Understand Kratom Product Labels
17:00
Kratom Products & Various Desired Effects; Physical Dependence
23:16
Different Kratom Usage Patterns, Opioid Dependence
32:53
Alkaloid Compounds, Nitrogen, Nicotine; Animals & Self-Experimentation
36:59
Sponsors: AG1 & ROKA
47:47
Medicine Development, Disconnection from Nature, Product Concentrations
51:05
Alkaloids & Natural Products, Opium Poppy, Coca Leaf, Tool: Kratom Leaf vs Ex
59:00

Transcript

Andrew Huberman: Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life. I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. My guest today is Dr. Chris...