As part of our summer replay series, we're revisiting one of our favorite conversations from the past year. Mark Zuckerberg and Dr. Priscilla Chan join Ben Horowitz, Vineeta Agarwala, and Erik Torenberg to discuss the Chan Zuckerberg Initiative's ambitious effort to help cure, prevent, and manage disease by the end of the century. Rather than funding individual breakthroughs, CZI is focused on building the tools and infrastructure that can accelerate scientific discovery across entire fields. The conversation explores Biohub, Cell Atlas, virtual cell models, open biological datasets, and the growing role of AI in helping researchers better understand human biology. They discuss why biology still lacks a "periodic table of elements," how AI could help scientists test hypotheses before running expensive experiments, and why pairing frontier biology with frontier AI may unlock a new era of medical discovery.   Resources: Follow Mark Zuckerberg on X: https://x.com/finkd [https://x.com/finkd] Follow Dr. Priscilla Chan on Instagram: https://www.instagram.com/priscillachan [https://www.instagram.com/priscillachan] Follow Ben Horowitz on X: https://x.com/bhorowitz [https://x.com/bhorowitz] Follow Vineeta Agarwala on X: https://x.com/vintweeta [https://x.com/vintweeta] Stay Updated: Find a16z on YouTube: YouTube [https://www.youtube.com/@a16z] Find a16z on X [https://x.com/a16z] Find a16z on LinkedIn [https://www.linkedin.com/company/a16z] Listen to the a16z Show on Spotify [https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX?si=3E8B3qT9TyiwAHJ7JnaKbg] Listen to the a16z Show on Apple Podcasts [https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711] Follow our host: https://twitter.com/eriktorenberg [https://twitter.com/eriktorenberg]   Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com [https://pcm.adswizz.com] for information about our collection and use of personal data for advertising.