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How Andrew Wilkinson Uses Opus 4.5 in His Work and Life

AI & I

Jan 21
AI & I

AI & I

Jan 21

Shownote

Entrepreneur Andrew Wilkinson used to sleep nine hours a night. Now he wakes up at 4 a.m. and goes straight to work—because he can’t wait to keep building with Anthropic’s latest model, Opus 4.5. Two years ago, Wilkinson was obsessed with vibe coding on ...

Highlights

In this episode, entrepreneur Andrew Wilkinson shares how cutting-edge AI tools like Claude Code and Opus 4.5 are transforming not only software development but also personal decision-making and business strategy. His journey from skepticism to full immersion reveals a new era where AI doesn't just assist but actively drives innovation.
01:07
ChatGPT advised me to grow a beard and I'm following its suggestions.
02:57
Opus 4.5 feels like having a high-paid engineering team
08:39
Designers will be most empowered by this new software era, as they can now take projects end-to-end.
16:51
The custom email client reduced my email load by 50% through automated triage and response drafting.
18:22
The app produces a JSON file with clinically-validated personality analysis using prompts from 'Made to Stick'.
33:17
AI meeting notes system texts users when detecting red flags like narcissistic behavior
35:17
AI may reinforce personal interpretations, leading to potential misjudgments if not used skillfully.
45:38
The bottleneck is reviewing and testing the code to ensure it works as intended
48:01
AI-generated outfit recommendations using weather data and a Google Sheet wardrobe inventory
59:19
Owning compute power may become a critical hedge against AI-driven job displacement.

Chapters

Start
00:00
Introduction
01:07
Why Opus 4.5 feels like the iPhone moment for vibe coding
02:48
Why designers have a unique advantage with AI
08:31
How Wilkinson built a custom email client with Claude Code
14:10
An AI trained on your relationship that predicts your fights
18:13
Using AI meeting notes to make your life better
30:40
Don't inject your opinion into prompts
35:11
Wilkinson’s Claude Code tips and workflows
40:21
Your personal stylist is a prompt away
47:59
How AI is changing the way Wilkinson invests in software
53:17

Transcript

Andrew Wilkinson: Over the last two weeks, I've been playing with Claude Code and Opus 4.5 and I am just blown away. It literally feels like I have like 30 free employees and they're just working 24-7 and I'm paying them like $40 a day. It's crazy. It's al...