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Big Ideas 2026: The Enterprise Orchestration Layer

The a16z Show

2025/12/23
The a16z Show

The a16z Show

2025/12/23
In 2026, artificial intelligence is no longer just a tool for automation—it's becoming the central nervous system of enterprise operations. This shift marks a fundamental rethinking of how work gets done across large organizations, moving beyond isolated AI assistants to interconnected systems that actively manage and execute complex processes.
The podcast explores how multi-agent AI systems are transforming enterprises by orchestrating workflows across departments and tools. These systems extract context from data and human activity to coordinate tasks, replacing linear processes with parallel, intelligent execution. Key enablers include unified data layers, AI-native architectures, and defensible vertical applications that leverage proprietary feedback loops. Early adopters in finance and insurance are already seeing gains in efficiency and revenue, with AI not only reducing costs but also improving outcomes through continuous learning. Human oversight remains critical to prevent cascading failures, while trust and integration challenges persist. The new operating model shifts power toward companies that can build coordinated agent teams within secure, scalable environments—turning AI into a strategic layer that drives commercial advantage rather than just incremental improvement.
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Enterprises will shift from isolated AI tools to multi-agent systems.
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Major financial institutions will adopt AI-native systems by 2026
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Vertical AI will move to multiplayer mode, with agents collaborating in workflows
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AI not only reduces costs but also enhances business performance
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The more cases Eve processes, the smarter the platform becomes.