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#845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment)

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#845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment)

The Tim Ferriss Show

Jan 07
The Tim Ferriss Show

The Tim Ferriss Show

Jan 07
OverviewShownoteHighlightsTranscriptChaptersPins

Shownote

Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute f...

Highlights

Tim Ferriss delves into the science and personal application of ketosis with Dr. Dominic D’Agostino, exploring how metabolic therapy can influence brain health, physical performance, and disease prevention. Their conversation moves beyond diet fads, focusing on measurable outcomes, biomarkers, and the evolving understanding of how fueling the body differently can reshape long-term health trajectories.
06:14
Ketosis elevates GABA and reduces glutamate, quieting the mind.
12:22
Dozens of tick-borne disease patients have seen positive results with ketosis.
24:52
The more one stays in ketosis, the easier it becomes due to metabolic memory.
38:05
High ketone utilization in a caloric deficit can cause false-negative blood ketone readings
46:09
Stretching the stomach from a big meal triggers the liver to produce more glucose
1:00:50
Rapid ketone rebound occurs after returning to ketosis following protein veggie days.
1:09:20
Discontinuing letrozole led to immediate cognitive recovery in a patient with ApoE3-4 and metabolic dysfunction.
1:20:43
Aim for a glucose ketone index (GKI) of 1–2 for three days per week to trigger autophagy.
1:29:38
L-beta-hydroxybutyrate improves blood flow to the brain and reduces peripheral vascular resistance.
1:35:48
Extended ketosis improves task completion speed and visual processing performance
1:38:40
1,3-butanediol can deplete NAD and ATP in the liver, posing risks for chronic use
1:55:15
1,3-butanediol or its based ketone esters may have an anti-endogenous ketosis effect and spike insulin
1:57:57
1,3-Butanediol produces narcotic-like intoxication similar to alcohol and can cause dependence.
2:07:59
Daily carb intake of 60–70 grams with one-third fiber can maintain ketosis when combined with MCTs.
2:12:30
Suspect fentanyl derivative contamination in over-the-counter gummies caused severe health effects.

Chapters

What Happens to Your Brain and Body When You Go Keto?
00:00
Can Ketosis Heal Tick-Borne Illness and Chemotherapy Side Effects?
12:22
How Does Metabolic Memory Make Ketosis Easier Over Time?
24:52
Why Are Your Ketone Readings Sometimes Misleading?
35:12
Do Big Meals Secretly Sabotage Ketosis?
46:09
How Much Protein Can You Eat Without Breaking Ketosis?
57:57
Is Ketosis a Shield Against Alzheimer’s and Brain Decline?
1:06:04
How Often Should You Cycle Into Ketosis for Long-Term Health?
1:18:01
What Is the Glucose Ketone Index — And Why Does It Matter?
1:23:46
How Do You Measure Cognitive Gains From Being in Ketosis?
1:32:53
Are Exogenous Ketones Safe for Daily Use?
1:38:40
What Liver Risks Come With Synthetic Ketone Supplements?
1:44:19
Can You Get Addicted to Ketone Esters?
1:57:57
Can You Eat Carbs and Still Stay in Ketosis?
2:05:28
What Happens When Supplements Are Contaminated?
2:10:43
Who’s Making Real-Food Ketogenic Options Accessible?
2:13:14
What’s Worth Promoting — And What’s Just Hype?
2:18:40

Transcript

Tim Ferriss: Hello, boys and girls, ladies and germs. This is Tim Ferriss. Welcome to another episode of The Tim Ferriss Show. This particular episode, I think, is probably my most practical, tactical discussion of ketosis. What the benefits are, how to im...