a16z's Joel De La Garza is joined by Nick Warner of Neo and Max Pollard of Cotool to discuss what happens when cybersecurity tools built to defend against humans and malware suddenly have to contend with AI agents. As frontier models become more capable of finding and exploiting vulnerabilities, many of the assumptions underlying traditional security are beginning to break. They explore why guardrails designed to stop AI-powered attackers can also prevent security teams from doing their jobs, why defenders increasingly need access to multiple models, and how agentic software creates an entirely new endpoint security problem. They also discuss why static signatures and even newer techniques like honeypots are struggling in a world where software can reason and act autonomously. Recorded around Black Hat, the conversation looks at how security teams are adapting in real time and why the same AI capabilities creating new attack surfaces could ultimately give defenders their biggest advantage yet.   Resources: Follow Nick on LinkedIn: https://www.linkedin.com/in/nicholaswarner/ [https://www.linkedin.com/in/nicholaswarner/] Follow Max on LinkedIn: https://www.linkedin.com/in/mmpollard/ [https://www.linkedin.com/in/mmpollard/] Follow Joel De La Garza on LinkedIn: https://www.linkedin.com/in/3448827723723234/ [https://www.linkedin.com/in/3448827723723234/] Stay Updated: Find a16z on YouTube: YouTube [https://www.youtube.com/@a16z] Find a16z on X [https://x.com/a16z] Find a16z on LinkedIn [https://www.linkedin.com/company/a16z] Listen to the a16z Show on Spotify [https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX?si=3E8B3qT9TyiwAHJ7JnaKbg] Listen to the a16z Show on Apple Podcasts [https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711] Follow our host: https://twitter.com/eriktorenberg [https://twitter.com/eriktorenberg] Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com [https://pcm.adswizz.com] for information about our collection and use of personal data for advertising.