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#842: The Story Behind EpiPen, The Rise of Food Allergies, and What Doctors Got Wrong

A surprising twist in public health advice may have inadvertently fueled a modern epidemic. This episode dives into the science and history behind food allergies, tracing how well-intentioned medical guidance could have triggered a surge in allergic reactions across generations.
The podcast explores how food allergies rose dramatically over recent decades, challenging long-held beliefs about infant diet and immune development. Early research on anaphylaxis laid the groundwork, but misguided recommendations to delay allergenic foods—like peanuts—likely contributed to increased sensitization. A pivotal comparison between Israeli and UK children revealed that early exposure, such as through peanut-based snacks, correlated with lower allergy rates. This led to landmark studies and updated guidelines promoting early introduction. Meanwhile, the EpiPen, originally a military invention, became a commercial powerhouse, especially after Mylan’s aggressive pricing and marketing strategies. Despite growing awareness and new treatments like Palforzia, allergy rates persist, partly due to lingering fears and slow adoption of preventive practices. Now, immunotherapy and early-life interventions offer hope for reducing the burden of food allergies, signaling a shift from reaction to prevention.
05:42
05:42
Food allergies may stem from a major medical and public-health blunder.
15:33
15:33
The immune system must learn to tolerate food proteins early in life or risk allergic reactions.
22:49
22:49
Dr. Gideon Lack's 2005 lecture revealed lower peanut allergy rates in early-exposure populations
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35:36
Lauren Gilmer survived an anaphylactic reaction at age eight after her mom used an EpiPen.
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44:47
Generic EpiPens are cheaper and more popular, yet still profitable.
47:51
47:51
Early peanut exposure in infancy can prevent peanut allergies
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54:41
The FDA approved Palforzia for peanut allergy treatment in 2020.