The Chan Zuckerberg Initiative (CZI) is accelerating the fight against all diseases by investing in large-scale, long-term scientific tools that traditional funding bodies like the NIH cannot support. Central to this effort is the Biohub, which integrates frontier biology with AI to build virtual cell models—digital simulations that allow scientists to test hypotheses in silico before costly lab work. A key milestone is the Cell Atlas, an open-source catalog of millions of cells that serves as biology’s missing 'periodic table,' enabling researchers to map cellular behavior with unprecedented precision. By unifying CZI and Biohub under AI leadership, the initiative fosters deep collaboration between biologists and engineers, prioritizing compute over physical labs. Virtual models reduce risk in drug discovery by simulating rare cell states and causal mechanisms, while user-friendly interfaces democratize access. Success hinges on cross-functional teams, proprietary datasets, and domain-specific AI models that outperform general ones. The goal is to enable personalized therapies by treating most diseases as rare conditions shaped by individual biology, ultimately compressing the timeline from basic science to real-world treatments.