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#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

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#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show

2025/12/03
The Tim Ferriss Show

The Tim Ferriss Show

2025/12/03
OverviewShownoteHighlightsTranscriptChaptersPins

Shownote

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)! This episode is brought to you by: Qlosi prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults: https://...

Highlights

In this wide-ranging conversation, Tim Ferriss and Kevin Rose dive into personal growth, cutting-edge science, and the evolving landscape of technology and relationships. The discussion moves fluidly from mental health innovations to the future of AI, offering candid reflections and forward-thinking insights.
00:57
Abstinence could be a trap, according to insights from 'Awareness' by Anthony de Mello.
07:16
Five days of accelerated TMS eliminated generalized anxiety for months
21:14
D-serine plus stimulation shows promising signals in patient cohorts
29:59
Josh Waitzkin can 'feel' chess moves and once sensed a cheat during simultaneous games
33:12
Reducing beta amyloid and tau buildup through quality sleep may delay Alzheimer’s progression.
46:22
Engineers who dismissed AI for coding three months ago now find it vastly improved.
55:50
At current valuations, the guest wouldn't invest in the top AI companies.
58:05
CEOs forcing engineers to use AI daily are the ones to watch for AI transformation
1:16:59
The Tank M3 push sled is effective for strength training and back pain relief on any surface
1:24:11
Use NotebookLM to create instant podcast primers on any topic
1:30:03
An investment can still be a win if you gain skills and relationships, even when the company fails.
1:32:12
Modern dating apps are designed to be addictive and undermine relationship commitment through recurring revenue models.
1:38:18
Objective reality has no place in relationship arguments—subjective stories matter more.
1:47:19
Rapamycin resulted in a 20% boost in lifespan for Toaster.
1:50:48
Qlosi is an FDA-approved eyedrop for presbyopia with fast-acting results and mild side effects.

Chapters

Start.
00:00
Why Kevin concluded nearly seven months of sobriety, and the 2-2-2 Rule he now follows for alcohol consumption.
00:52
My recent adventures in accelerated TMS and bioelectric medicine.
07:12
The tragic death of Nolan Williams and funding future research through the Saisei Foundation.
21:09
Aphantasia vs. hyperphantasia, and Joshua Waitzkin's ability to "feel" chess.
24:23
DORAs for sleep and Alzheimer's prevention: Matt Walker, Belsomra, and the terrifying p-tau blood test.
33:12
Dale Bredesen's kitchen-sink approach to dementia and the ketogenic connection.
41:21
The rapid pace of AI development: Why your opinion from three months ago is already obsolete.
46:22
Google's full-stack advantage: TPUs, Gemini 3, and why they were built for this moment.
49:40
The future of venture capital: Seed rounds shift later as entrepreneurs gain leverage.
52:50
Kevin's three AI investment buckets: Power, data centers, and bloated companies ripe for automation.
58:05
Holiday gift ideas and recommended reading.
1:02:05
The Way App and meditation with Zen master Henry Shukman.
1:17:41
Kevin's AI stack: Nothing earbuds, Sandbar ring, Notion AI, and the NotebookLM podcast hack.
1:21:44
Oboe.fyi: The AI learning platform and my investment philosophy.
1:26:58
My new girlfriend, the perils of modern dating apps, and building a communication toolkit.
1:32:09
Terry Real's relationship wisdom: Why objective reality has no place in an argument.
1:38:17
Dog updates: Molly, a new puppy, and Toaster on rapamycin.
1:47:18
Parting thoughts and happy holidays.
1:47:58

Transcript

Kevin Rose: Kevin, Kevin. Good to see you. Tim Ferriss: Tim, Tim. Another episode of The Random Show. Glad to be back. Kevin Rose: Another episode of The Random Show. You look very dashing for people who can't see you. You have sort of hair slicked back,...