Max Cook of Coatue predicts the keyboard and mouse are dying, replaced by natural language interaction with agentic AI models, a shift already seen among Coatue investors. The open-source vs. closed model debate was central, with Matan Grinberg forecasting that 90% of tokens will go to open models within 12 months due to performance and cost advantages, while Cook argues the debate is premature as production workflows are still early. Mark Papermaster of AMD explained how agentic AI is reimagining end-to-end workflows, prompting AMD to increase CPU-to-GPU ratios. Pim de Witte of General Intuition countered that most AI is glorified data science, betting on good datasets. Philip Johnston of Starcloud predicted the SpaceX IPO will be historically undervalued due to its dominance in emerging space industries like orbital data centers. Ramin Hasani of Liquid AI advocated for a three-axis approach to foundation models—capability, efficiency, and substrate—to deliver real enterprise value, exemplified by their work with Mercedes-Benz.