Dr. Eric Topol discusses strategies for extending healthspan by preventing major age-related diseases through evidence-based practices. He highlights the importance of studying super-agers—individuals who remain disease-free into old age—and emphasizes emerging tools like AI, polygenic risk scores, and GLP-1 drugs. These innovations enable personalized prevention strategies that account for genetic predispositions and lifestyle factors. The conversation also addresses the need for cultural and economic shifts in healthcare systems to prioritize prevention over treatment, advocating for more efficient, cost-effective approaches. Ultimately, combining technology with personal responsibility offers hope for healthier aging worldwide.