Bill Vass discusses the transformative role of AI in government, including its use on the International Space Station and at the VA to streamline claims processing. He highlights the need for guardrails due to risks like AI hallucinations and questions about over-reliance. The conversation also explores autonomous driving, where simulation tools like Nvidia’s Omniverse are training future systems. Vass emphasizes the importance of U.S. leadership in AI and quantum computing, particularly in the face of global competition. Quantum computing’s early applications in material science and chemistry are examined, along with the technical hurdles in error correction and scalability. Finally, Vass reflects on leadership principles, public-private collaboration, and lessons from the tech industry on adapting to change.