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How Mitochondria Control Your Metabolism | Dr. Jared Rutter

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How Mitochondria Control Your Metabolism | Dr. Jared Rutter

Huberman Lab

22 HOURS AGO
Huberman Lab

Huberman Lab

22 HOURS AGO
OverviewShownoteHighlightsTranscriptChaptersPins

Shownote

Dr. Jared Rutter, PhD, Professor of Biochemistry at the University of Utah and Howard Hughes Medical Institute Investigator, is a leading expert on mitochondria and metabolism. He explains how mitochondria produce the energy for your cells to work but also...

Highlights

Dr. Jared Rutter explains how mitochondria do far more than generate ATP: they help cells sense resources, choose between energy production and growth, and influence aging, disease, and cancer.
04:46
Whole-body metabolism is cellular metabolism multiplied across the body
10:53
Mitochondria made complex life possible
16:34
Mitochondria preserve a relic of their bacterial ancestry
21:06
Mitochondria make energy where it is needed
27:33
Insulin tells cells that the organism has eaten
35:19
Food can become energy or biomass
39:19
Cancer turns resource allocation toward making more cells
49:28
Are humans just vehicles for their microbiota?
53:25
MPC is the gateway for pyruvate into mitochondria
1:00:49
Cells constantly monitor their energy supply
1:09:05
The heart can survive, but not indefinitely, without MPC
1:15:16
Cells must choose between growing and functioning.
1:22:44
Genetics revealed what the MPC proteins do.
1:27:31
Lactate can be a fuel
1:36:03
The Warburg effect reflects cellular resource allocation
1:40:04
A tiny resistant population can rebuild a tumor
1:45:06
Cancer should be classified by its biology, not just its location
1:52:44
The key challenge is knowing what to measure
1:58:02
Excess mitochondrial energy can become cellular damage
2:00:04
Metabolism is a constellation of metabolisms

Chapters

Jared Rutter
00:00
Metabolism, Cells; Aging
02:29
Mitochondria, Origin & Cell Complexity
08:36
Sponsors: Joovv & BetterHelp
13:07
Mitochondria Genome, Inheritance
15:16
Mitochondria & Spatial Distribution; Cell-Specific Metabolism
18:18
Nutrient Energy, Hormones, Fat Cells
25:59
Glucose, ATP Conversion, Pyruvate
31:13
Cell Choice: Energy or Growth, Cancer; Virus
36:41
Sponsors: AG1 & Eight Sleep
46:02
Microbiome, Role of Humans
48:36
Molecule Discovery Process, MPC1, MPC2
51:44
Cell Resource Sensing, Fasting, Glucagon, Fat Cells; Neurons, Heart
59:42
Cell Resource Allocation, MPC, Heart Failure; Disease
1:07:03
Sponsor: Function
1:11:46
Cell Size vs Fuel Balance, Cell Identity & Disease
1:13:24
MPC Discovery, Genetics, Model Systems
1:20:43
Lactate, Oxygen, Exercise; Energy Prioritization Hierarchy
1:24:29
Cancer, Mutations, Metabolism Changes & Warburg Effect
1:31:32
Cancer Challenges & Therapies
1:36:18
Therapy Combinations, Unique Cancer Mutations & Metabolism
1:43:00
Technology to Visualize Metabolism; Disease, Metabolism & Scents
1:48:31
Excess Energy & Mitochondria, Reactive Oxygen Species
1:56:34
Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
2:01:12

Transcript

Dr. Jared Rutter: There's a widely accepted hypothesis that mitochondria with excess energy leads to problems. Many people that are listening have probably heard of reactive oxygen species. This is forms of oxygen that become reactive and end up spinning o...