In loving memory of Nolan Williams (1982-2025): ⁠https://stan.md/3Qle2zp⁠ [https://stan.md/3Qle2zp] In this Huberman Lab Essentials [https://www.hubermanlab.com/essentials] episode, my guest is Dr. Nolan Williams, MD, a triple board-certified psychiatrist and neurologist. We discuss cutting-edge treatments for depression and post-traumatic stress disorder (PTSD), including transcranial magnetic stimulation, neuromodulation, and psychedelic-assisted therapies. We also discuss the neurobiology and therapeutic potential of specific psychedelic compounds, including psilocybin, MDMA, ibogaine, and ayahuasca. Read the episode show notes at hubermanlab.com [https://www.hubermanlab.com/episode/essentials-psychedelics-neurostimulation-for-brain-rewiring-nolan-williams]. Thank you to our sponsors AG1: https://drinkag1.com/huberman [https://drinkag1.com/huberman] Function: https://functionhealth.com/huberman [https://functionhealth.com/huberman] BetterHelp: https://betterhelp.com/huberman [https://betterhelp.com/huberman] Timestamps (00:00:00) Nolan Williams (00:00:21) Depression (00:02:45) Heart & Mind Connection, Transcranial Magnetic Stimulation (TMS) (00:05:15) TMS for Depression (00:07:47) Sponsor: Function (00:09:24) SSRIs & Chemical imbalance, TMS, Psychedelics (00:15:24) Psilocybin, MDMA, Trauma (00:18:21) MDMA Clinical Trials & PTSD; Psilocybin & Depression (00:20:18) Sponsor: BetterHelp (00:21:38) Psilocybin, Brain Connectivity & Depression (00:23:59) Ibogaine, Empathy; Psychedelic Breakthrough & Risk (00:30:36) Ayahuasca, Behavior Change, Prisoners (00:34:46) Sponsor: AG1 (00:36:05) Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) (00:40:07) Acknowledgements Disclaimer & Disclosures [https://www.hubermanlab.com/disclaimer] Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]