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Essentials: Erasing Fears & Traumas Using Modern Neuroscience

Overview

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Highlights

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Essentials: Erasing Fears & Traumas Using Modern Neuroscience

Huberman Lab

2025/11/06
Huberman Lab

Huberman Lab

2025/11/06
OverviewShownoteHighlightsTranscriptChaptersPins

Shownote

In this Huberman Lab Essentials episode, I explore the neuroscience of fear and trauma and how to effectively process and eliminate traumatic responses. I explain why successful fear treatment requires both extinction of the old fearful response and repla...

Highlights

This episode delves into the intricate neuroscience behind fear and trauma, examining how the brain encodes and responds to threats on both biological and psychological levels. By exploring the underlying neural mechanisms, the discussion sets the stage for understanding modern, science-backed strategies aimed at dismantling persistent fear responses and promoting lasting emotional resilience.
08:18
The HPA axis can alter gene expression through long-lasting hormonal feedback.
09:20
The amygdala can activate the dopamine system to replace fearful memories.
20:50
Recounting trauma in detail reduces physiological anxiety over time.
29:48
MDMA increases dopamine and serotonin simultaneously, enabling rapid relearning in trauma therapy
33:19
Cyclic hyperventilation can enhance trauma therapy by increasing autonomic arousal
36:01
Saffron (30 mg orally) and inositol (18 grams for a month) are effective supplements for reducing anxiety
38:18
Safe re-exposure to trauma can promote extinction of fear responses.

Chapters

Introducing Fear & Trauma
00:00
What is Fear?
00:17
Autonomic Arousal: "Alertness" vs. "Calmness"
01:03
Fear vs. Stress & Anxiety
02:05
"The Threat Reflex": Neural Circuits for Fear
09:20
Cognitive (Narrative) Therapies for Fear
20:50
PTSD Treatments: Ketamine, MDMA, Oxytocin
26:35
Deliberate Brief Stress Can Erase Fears & Trauma
33:11
Nutrition, Sleep, & Other General Support Erasing Fear & Trauma
35:51
Recap
38:18

Transcript

Andrew Huberman: Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance. I'm Andrew Huberman, and I'm a professor of neurobiology and oph...