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Behaviors That Alter Your Genes to Improve Your Health & Performance | Dr. Melissa Ilardo

Huberman Lab

2025/05/26
Huberman Lab

Huberman Lab

2025/05/26
This podcast features Dr. Melissa Ilardo, a professor of biomedical informatics at the University of Utah, discussing the intricate relationship between human genetics and behavior. The conversation delves into how specific actions can alter gene expression to enhance health and performance, including insights from her research on breath-hold diving and its physiological impacts.
Dr. Ilardo explores how behaviors influence genetic expression and organ function, focusing on the mammalian dive reflex and its effects on spleen size and oxygen availability. She highlights the role of epigenetics in rapid genetic adaptation, such as those seen in populations like the Bajau sea nomads, who have evolved enhanced diving abilities over generations. Mate selection is also discussed, emphasizing the immune system's role in attraction based on differing major histocompatibility complexes. The podcast further examines the ethical implications of gene editing technologies, like CRISPR, and their potential to cure diseases in humans. Additionally, Dr. Ilardo explains how cultural practices and environmental pressures contribute to evolutionary changes, showcasing the dynamic interplay between nature and nurture.
05:24
05:24
All blue-eyed people descend from one individual
13:40
13:40
Humans prefer the smell of mates with different immune systems.
18:51
18:51
Human evolution relies on genetic variation and adaptation to environmental changes.
28:11
28:11
Free-diving could be a driver of evolution in sea nomad populations.
32:52
32:52
Bajau diving culture correlates diving skills with social benefits.
35:36
35:36
Holding breath triggers heart rate slowing and spleen contraction.
42:47
42:47
AG1 features bioavailable nutrients and enhanced probiotics.