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Female Hormone Health, PCOS, Endometriosis, Fertility & Breast Cancer | Dr. Thaïs Aliabadi

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Female Hormone Health, PCOS, Endometriosis, Fertility & Breast Cancer | Dr. Thaïs Aliabadi

Huberman Lab

6 DAYS AGO

Female Hormone Health, PCOS, Endometriosis, Fertility & Breast Cancer | Dr. Thaïs Aliabadi

Female Hormone Health, PCOS, Endometriosis, Fertility & Breast Cancer | Dr. Thaïs Aliabadi

Huberman Lab

Huberman Lab

6 DAYS AGO

Overview Shownote Highlights Transcript Chapters Pins

Shownote

My guest is Dr. Thaïs Aliabadi, MD, board-certified OB/GYN, surgeon and leading expert in women's health. We discuss polycystic ovary syndrome (PCOS) and endometriosis, two very common yet frequently undiagnosed causes of female infertility. Dr. Aliabadi e...

Highlights

In this insightful conversation, Dr. Thaïs Aliabadi, a board-certified OB/GYN and women's health expert, sheds light on two widespread yet underdiagnosed conditions that significantly impact female reproductive health. She emphasizes the critical need for greater awareness, early detection, and patient empowerment in navigating complex hormonal disorders.

02:58

Symptoms of PCOS and endometriosis are frequently dismissed, leading to undiagnosed infertility

09:30

PCOS and endometriosis, major causes of infertility, can be self-diagnosed.

14:07

PCOS and endometriosis education must be mandatory in schools

15:28

High AMH in PCOS doesn't mean good-quality eggs

21:29

GLP-1s have been used for weight loss in PCOS patients since 2014.

24:36

90% of PCOS cases are undiagnosed due to systemic barriers in diagnostic imaging.

30:42

Treating underlying PCOS can improve mood disorders without evidence that antidepressants cause PCOS

38:48

Only 20-30% of PCOS patients ovulate, and many have poor egg quality.

43:26

Visceral fat contributes to inflammation and worsens insulin resistance in PCOS, even in lean individuals

49:11

Androgens in PCOS disrupt dopamine and serotonin balance in the brain

52:33

High AMH in PCOS may reflect non-ovulating follicles, not fertility potential

58:34

90% of PCOS and endometriosis cases go undiagnosed despite being leading causes of infertility

1:03:50

High-dose metformin (750mg twice daily) is more effective for insulin resistance in PCOS

1:09:45

GLP-1s like Trulicity have transformed lives by regulating insulin and improving PCOS symptoms

1:17:44

GLP-1s reduce alcohol cravings because they're tied to sugar cravings in brain dysregulation

1:19:14

Over 50% of PCOS patients may also have endometriosis, impacting fertility treatment.

1:26:06

Women with PCOS should freeze eggs before 30 for optimal fertility preservation

1:34:58

Normal AMH and menstruation don't guarantee reproductive normality

1:38:52

Listening to patients achieves 99.9% accuracy in diagnosing endometriosis

1:39:30

Painful periods disrupt life and are a key symptom of endometriosis

1:42:30

A 50-year-old patient suffered for years with classic endometriosis symptoms without diagnosis, exposing critical gaps in women's healthcare.

1:47:04

Endometriosis implants self-sustain through local estrogen production

1:50:37

Inflammation from endometriosis creates a hostile environment for sperm and embryos

1:54:31

Function detected elevated mercury levels in the speaker, leading to targeted reduction strategies.

1:58:48

Normal ultrasound or MRI doesn't rule out endometriosis — diagnosis requires clinical correlation and patient advocacy

2:01:38

Only one in 100 gynecologists is trained for laparoscopic endometriosis surgery.

2:08:00

When a woman says something's wrong with her body, it usually is.

2:15:12

Explaining medications to PCOS patients improves treatment compliance

2:16:09

0.1 of typical AMH units corresponds to one egg, and ultrasound may miss endometriosis

2:20:45

GnRH antagonists are effective for painful sex and periods but limited to two years due to bone loss.

2:22:40

Stromal endometriosis lacks glandular tissue and is often missed in laparoscopy

2:23:54

Endometriosis and PCOS patients are at higher risk for postpartum depression due to their life experiences

2:32:21

Every woman should have an annual pelvic ultrasound as part of a Well Woman Exam.

2:34:07

Patients can perform basic infertility checks themselves, as some doctors may overlook key factors.

2:44:35

A woman with 37% lifetime risk had cancer found during double mastectomy after being denied care

2:50:30

Endometriosis is an autoimmune disease.

2:55:59

Completely cutting carbs is not sustainable, especially for young patients

3:00:16

Endometriosis patients on HRT need progesterone even after hysterectomy to prevent implant stimulation.

3:00:42

Reducing visceral fat and insulin resistance can increase ovulation in PCOS

Chapters

Thaïs Aliabadi

00:00

Why Endometriosis & Polycystic Ovary Syndrome (PCOS) Go Undiagnosed

02:56

Infertility, Tool: Early Screening

08:16

Sponsors: Lingo & Our Place

10:54

Women's Health Education Gap

14:07

PCOS Overview: Symptoms, Diagnosis, AMH, Disordered Eating

15:24

Irregular Periods, Teenage PCOS Diagnosis

21:28

Diagnosis, Pelvic Ultrasound; PCOS Naming

24:36

Thinning Hair & Acne; 4 PCOS Phenotypes; Mood & Treatment

27:49

Underlying Pillars of PCOS; HPA Axis, Androgens, Menstruation & Ovulation

35:54

Insulin Resistance & PCOS, Visceral Fat & Inflammation

40:30

Sponsors: AGZ by AG1 & Joovv

46:30

PCOS, Chronic Inflammation, Genetics & Lifestyle; Mood

49:10

PCOS, Fertility, Freezing Eggs, Tool: Egg Count & AMH Range By Age

52:31

Women's Health Education, AI, Clinicians; Cataracts Analogy

58:34

Stress; PCOS Treatment, Birth Control, Insulin Resistance & Metformin

1:01:20

PCOS Risk Calculator, Supplements, Lifestyle Factors; GLP-1s

1:06:44

Berberine, Metformin; GLP-1s, Food Anxiety & Alcohol

1:12:32

PCOS Prescriptions & Fertility; PCOS Co-Occurrence with Endometriosis

1:19:13

Sponsor: LMNT

1:21:56

PCOS Treatment, Freezing Eggs, Egg Quality; Advocate For Your Health

1:23:16

PCOS Key Takeaways: Symptoms, Tests, Supplements & Lifestyle

1:32:02

Undiagnosed Endometriosis, Fertility

1:36:03

Endometriosis: Symptoms, Diagnosis, Painful Periods, Infertility

1:39:26

Male vs Female Health Issues, Undiagnosed Endometriosis

1:42:30

Inflammation, Ectopic Implants, Chronic Pelvic Pain; Adenomyosis

1:47:01

Egg Quality, Endometriosis, Tools: Egg Counts; Pelvic Ultrasound

1:50:36

Sponsor: Function

1:54:29

Pain & Health Testing, Tool: Endometriosis Symptoms, Screening & Tests

1:56:13

Treatment, Surgery, Different Types of Endometriosis

2:01:32

Endometriosis Causes, Inflammation; Incidence, PCOS

2:05:22

Obstetrics & Gynecology Separation, Surgery

2:11:58

Endometriosis Key Takeaways: Symptoms, Treatment & Diagnosis

2:16:00

Treatment, Estrogen & Progesterone, Birth Control, GnRH Antagonists

2:17:04

Endometriosis Stage & Pain, Endometriosis Types

2:22:39

Pregnancy; Postpartum Depression, Menopause; Frustration for Patients

2:23:49

Fibroids, Surgery, Uterine Septum, Tool: Pelvic Ultrasound

2:29:55

Tool: Assessing Your & Partner's Fertility; Autoimmune Conditions

2:34:05

Breast Cancer, Tool: Lifetime Risk Calculator & Breast Imaging; Mastectomy

2:37:51

Endometriosis Tests, Autoimmune Disease; Brain Fog & Menopause; Inositol

2:49:47

Undiagnosed Infertility; PMDD Treatment; Fasting & Low-Carbohydrate Diets

2:53:06

Hair Loss & Perimenopause; Egg Quality; Endometriosis & Menopause

2:57:21

Increase Progesterone; Diet, Hormone & Menopause; Prolong Fertility

3:00:40

Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter

3:04:54

Transcript

Thaïs Aliabadi: Every single ophthalmologist knows about cataract. Andrew Huberman: Yes. Most common form of blindness. Thaïs Aliabadi: So it would be rare for you to go to an ophthalmologist with cataract and not get diagnosed, correct? Correct. So why ...