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How to Overcome Addiction to Substances or Behaviors | Dr. Keith Humphreys

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How to Overcome Addiction to Substances or Behaviors | Dr. Keith Humphreys

Huberman Lab

2 DAYS AGO

How to Overcome Addiction to Substances or Behaviors | Dr. Keith Humphreys

How to Overcome Addiction to Substances or Behaviors | Dr. Keith Humphreys

Huberman Lab

Huberman Lab

2 DAYS AGO

Overview Shownote Highlights Transcript Chapters Pins

Shownote

Dr. Keith Humphreys is a professor of psychiatry and behavioral sciences at Stanford School of Medicine and a leading expert on treating addictions, drug laws and policy. We discuss all the major addictive substances and behaviors, including alcohol, opioi...

Highlights

In this in-depth conversation, Dr. Keith Humphreys, a leading expert in addiction and psychiatric policy, explores the biological, psychological, and societal dimensions of substance use and behavioral addictions. The discussion moves beyond surface-level narratives to examine how brain science, personal history, and environmental design converge to shape addictive behaviors.

08:50

Recovered addicts may shift to new compulsive behaviors as the underlying predisposition finds a new outlet

11:46

8%–10% of people experience alcohol as energizing and more rewarding due to genetic factors

26:12

Cancer risks from alcohol exceed any potential heart benefits, with no net mortality reduction from drinking.

36:58

One should consider genetic predisposition, weigh cardiac benefits against cancer risk, think about vulnerabilities of actions and words when drinking, and then make an informed decision.

44:02

Many cannabis edible products are poorly made with unevenly distributed ingredients

47:52

Frequent cannabis use undermines short-term memory, concentration, and motivation.

59:48

Slot machines now generate over 80% of casino revenue by exploiting the brain's craving for novelty, not winning.

1:08:16

Kids are more likely to have trouble with alcohol than cannabis.

1:11:46

Clinical use of psilocybin shows 60-70% relief for major depression

1:25:44

TMS can change lives for those with treatment-resistant depression.

1:34:16

Nolan Williams' Ibogaine work showed documented brain changes in PTSD patients

1:41:43

Untreated ADHD may pose a greater addiction risk than using stimulant medications.

1:44:07

Relief from withdrawal is often mistaken for a drug's beneficial effect.

1:48:47

Many Americans are in recovery, and early-stage recovery has higher success odds.

1:55:25

When addicts get sober, their true selves emerge, revealing the distortion caused by addiction.

2:08:44

Addiction can significantly change a person over time, causing mismatched marriages not from poor initial choices but personal transformation.

2:09:56

Nucleus accumbens activation predicts relapse better than self-reporting in methamphetamine addiction

2:24:27

91% of people seeking alcohol treatment were pressured to quit, showing the role of external motivation in recovery.

2:28:46

A recent budget bill cuts about a trillion dollars from Medicaid over the coming years, threatening addiction treatment access for low-income Americans.

2:31:50

AA and 12-step facilitation counseling showed high abstinence rates in a Cochrane review

2:38:11

AA is not a cult as it doesn't take members' money and allows anyone to leave freely.

2:47:28

Patients on Ozempic reported reduced alcohol cravings as a side effect

2:58:12

Society must build social norms around social media like those for alcohol

3:01:44

Genes are a risk, not destiny—recovery can break the chain of addiction in one generation.

3:06:52

The Big Book uses stories to show recovery is possible for everyone

3:10:53

Being the last friend of the dying is an honor and helps overcome fear of death.

3:13:58

Heavy substance use is often an attempt to escape unpleasant truths like death, suffering, or abuse.

3:21:01

Not using substances is the best way to avoid addiction.

Chapters

Keith Humphreys

00:00

Addiction; Genetic Risk

03:22

Alcohol Use Disorder & Alcoholism; Genetic Predisposition & Addiction Risk

09:14

Sponsors: David & BetterHelp

18:03

Women & Alcohol Use; Young Adults; Cannabis Use

20:37

Health Benefit to Alcohol?, Red Wine, Cancer Risk; Social Pressure

23:36

Alcohol in Social Gatherings, Social Anxiety, Vulnerability, Work & Dates

31:47

Old vs New Cannabis & THC Levels; Smoked vs Edible Forms

37:41

Cannabis & Psychosis Risk; Cardiac Health; Youth Cannabis Use & Transition to Adulthood

44:38

Sponsor: AG1

52:29

Industries of Addiction, Regulation; Gambling, Slot Machines, Novelty; Casinos

54:13

Decriminalization vs Legalization; Cannabis, Gateway Drug?

1:05:28

Psylocibin or LSD, Addiction Treatment; Microdosing, Clinical Trial Challenges

1:08:50

Sponsor: Helix Sleep

1:18:58

Brain Plasticity & Age; Ketamine, Depression, Transcranial Magnetic Stimulation (TMS)

1:20:32

SSRIs, Mass Shootings, Suicide, Side Effects; Drug Approval; Ibogaine & PTSD

1:28:10

Caffeine Addiction?; Stimulants & Rehab; Prescription Stimulants & ADHD

1:36:10

Nicotine, Mistaking Withdrawal for Benefit

1:44:04

Sponsor: LMNT

1:47:24

Tool: How to Talk to Someone with Addiction

1:48:44

Perception of Addicts, Character Defect, Pain

1:55:23

Overcoming Addiction, Immediate Rewards, AA; Addict & Co-Dependency?

2:00:58

Longterm Drug Use, Dopamine, Cues & Relapse; Social Media

2:09:53

Brain Stimulation, TMS; Homelessness, Substance Use & Rehab

2:16:21

Addiction Treatment Policy, Rehab & Insurance

2:26:11

Tool: 12-Step Programs, AA, Accessibility & Benefits

2:29:08

AA, Higher Power, Cult?; Flexibility, Tool: Open AA Meetings

2:38:08

GLP-1s, Weight Loss, Alcohol Addiction; Pharmaceutical Advertisements

2:44:38

Social Media Addiction, Tool: Avoiding Social Media Strategies

2:52:39

“Failure to Launch”, Youth, Video Games, Social Media; Recovery Pathways

2:58:36

AA as an Action Program, Tool: Try Different AA Meetings

3:04:13

Hospice, Death, Overcoming Fear of Death

3:08:21

Addiction to Escape Death?, Desire for Oblivion

3:13:54

Men vs Women & Addiction; Lying; Relapse; Fentanyl & Addiction Advice

3:18:11

Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter

3:24:27

Transcript

Keith Humphreys: If someone says, I want to quit smoking, a good clinician will say, why would you want to do that? Just say, so tell me, what do you want to get out of this? Because it's work. I mean, I'm happy to work with you, but what is it? What are y...