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Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

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Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

Huberman Lab

2025/12/25
Huberman Lab

Huberman Lab

2025/12/25
OverviewShownoteHighlightsTranscriptChaptersPins

Shownote

In this Huberman Lab Essentials episode, my guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health. We explain how to improve hormone lev...

Highlights

In this episode, Dr. Andrew Huberman sits down with Dr. Kyle Gillett, a dual board-certified physician in family and obesity medicine, to explore the science of hormone optimization across the lifespan. The conversation delves into clinical strategies for assessing hormonal health, emphasizing the importance of personalized, data-driven approaches grounded in biology and behavior.
03:15
Diet and exercise are the most powerful levers for hormone optimization.
06:17
Diet should be individualized, like different cars need different fuels.
07:25
More zone 2 exercise makes long-term caloric restriction less crucial
08:45
Intermittent fasting can boost growth hormone and IGF-1 levels, especially in older adults
11:09
TRT increases sleep apnea risk in first months, especially at high doses
13:28
Testosterone is as important as estrogen and progesterone for women's health optimization
15:23
Maui Nui's summer sausage has 20g of protein, 110 calories, and zero sugar.
19:00
Dutasteride mesotherapy allows localized reduction of DHT in the scalp, preserving function in other tissues.
22:44
Myo-inositol is an insulin sensitizer, while D-chiro-inositol has weak antiandrogen effects depending on gender
23:13
Smoked marijuana increases aromatase, raising estrogen and lowering testosterone
24:48
Testosterone doesn't cause prostate cancer but can promote its growth if present
26:06
Estrogen upregulates the prolactin gene, and prolactin inhibits testosterone release.
29:10
Time apart can re-ignite relationship excitement by restoring dopamine levels
33:58
BPC 157 increases blood flow to injured tissues but may promote tumor growth in cancer-prone individuals
36:42
Melanotan is used to treat hypoactive sexual disorder in women under the name Bremelanotide (PT141).
38:45
Spiritual, mental, and physical health are interconnected like a Venn diagram

Chapters

Kyle Gillett
00:00
Hormone Health; Women vs Men, Tool: Hormone Testing
00:36
Tool: Big 6 Lifestyle Pillars to Optimize Hormone Health
02:35
Sponsor: AG1
04:32
Diet, Individualization; Bloodwork & Frequency
06:17
Exercise, Zone 2 Cardio; Caloric Restriction
07:20
Intermittent Fasting, Growth Hormone, IGF-1
08:36
Hormones & Sleep, Growth Hormone, Menopause, Andropause, TRT
11:05
Testosterone & Women, SHGB
13:28
Sponsor: Maui Nui
15:19
Dihydrotestosterone (DHT), Androgens; Turmeric & Black Pepper; Hair Loss
16:34
Polycystic Ovarian Syndrome (PCOS), Symptoms, Metformin, Inositol
19:47
Cannabis, Alcohol, Testosterone
23:13
Males & Testosterone, TRT, Prostate Cancer
24:48
Prolactin, Dopamine "Wave Pool", Tool: Casein & Gluten
26:04
Sponsor: Function
27:23
Social Relationships & Hormones, Tool: Planning for Crisis
29:03
Peptides, Growth Hormone & Risk; BPC 157, Sourcing & LPS
31:02
Melanotan, Uses & Risks
36:42
Spiritual Health, Interdisciplinary Health Integration
38:45
Caffeine & Hormones, Sleep; Acknowledgements
41:23

Transcript

Andrew Huberman: Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance. I'm Andrew Huberman, and I'm a professor of neurobiology and oph...