Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett
Huberman Lab
2025/12/25
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett
Huberman Lab
2025/12/25
In this episode, Dr. Andrew Huberman sits down with Dr. Kyle Gillett, a dual board-certified physician in family and obesity medicine, to explore the science of hormone optimization across the lifespan. The conversation delves into clinical strategies for assessing hormonal health, emphasizing the importance of personalized, data-driven approaches grounded in biology and behavior.
The discussion highlights the foundational role of lifestyle in regulating hormones, focusing on six key pillars: nutrition, exercise, sleep, stress management, sunlight exposure, and spiritual well-being. The doctors emphasize individualized dietary plans supported by regular blood testing every three to six months, and they examine how zone 2 cardio benefits metabolic health without suppressing testosterone like caloric restriction might. Intermittent fasting is noted for boosting growth hormone and IGF-1, especially in aging populations. They address sex-specific concerns, including testosterone's role in women, DHT’s link to motivation and hair loss, and PCOS management using inositol and metformin. Risks associated with alcohol, cannabis, and peptide use—such as BPC 157 and Melanotan—are reviewed, along with the importance of medical supervision. The dialogue also covers TRT and prostate health, prolactin-dopamine balance, and the impact of social relationships and spirituality on hormonal regulation, advocating for integrated, patient-centered care.
03:15
03:15
Diet and exercise are the most powerful levers for hormone optimization.
06:17
06:17
Diet should be individualized, like different cars need different fuels.
07:25
07:25
More zone 2 exercise makes long-term caloric restriction less crucial
08:45
08:45
Intermittent fasting can boost growth hormone and IGF-1 levels, especially in older adults
11:09
11:09
TRT increases sleep apnea risk in first months, especially at high doses
13:28
13:28
Testosterone is as important as estrogen and progesterone for women's health optimization
15:23
15:23
Maui Nui's summer sausage has 20g of protein, 110 calories, and zero sugar.
19:00
19:00
Dutasteride mesotherapy allows localized reduction of DHT in the scalp, preserving function in other tissues.
22:44
22:44
Myo-inositol is an insulin sensitizer, while D-chiro-inositol has weak antiandrogen effects depending on gender
23:13
23:13
Smoked marijuana increases aromatase, raising estrogen and lowering testosterone
24:48
24:48
Testosterone doesn't cause prostate cancer but can promote its growth if present
26:06
26:06
Estrogen upregulates the prolactin gene, and prolactin inhibits testosterone release.
29:10
29:10
Time apart can re-ignite relationship excitement by restoring dopamine levels
33:58
33:58
BPC 157 increases blood flow to injured tissues but may promote tumor growth in cancer-prone individuals
36:42
36:42
Melanotan is used to treat hypoactive sexual disorder in women under the name Bremelanotide (PT141).
38:45
38:45
Spiritual, mental, and physical health are interconnected like a Venn diagram
